For a short time, Carlisle lived with the Volturi, though he eventually left and traveled to the New World. While treating patients with the Spanish Influenza, he met a woman who begged him to do whatever he could to save her son, Edward. Out of loneliness, Carlisle transformed him into a vampire and Edward became his companion. Soon after, in 1921, Carlisle moved to Wisconsin where he treated Esme, after a failed suicide attempt brought on by the loss of her infant son. Carlisle felt compelled to save her life and turned her into a vampire, subsequently falling in love with her, and marrying her later on. Carlisle then transformed Rosalie Hale, a young woman who was almost killed by her drunken fiancé and his friends in Rochester, New York, and left in the street to die. Later, while hunting, Rosalie found a young man named Emmett who had been mauled by a bear, and carried him over 100 miles to Carlisle. Carlisle then changed Emmett, since Rosalie was unwilling to do it herself for fear of blood lust overwhelming her. After Carlisle changed Emmett, Carlisle and his family moved to Hoquiam, Washington, where they made a treaty with the Quileute Native American tribe, that the Quileutes would leave the Cullens alone if the Cullen family did not bite any humans or trespass on their land. The Cullens agreed to this treaty, and lived in relative peace until they had to move on. Between the Cullens' first and second stay in Forks, Alice and Jasper joined his coven as well, having found Carlisle on their own. Throughout the Twilight saga, Carlisle works as a doctor, acting as the coven leader and offering medical advice and help when Bella is pregnant in Breaking Dawn.
Carlisle was portrayed by Peter Facinelli in the Twilight film.
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